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Indigenous Guyanese women have a high rate of cervical cancer and high-grade dysplasia, with an apparent predominance of HPV 16 and 18 in invasive cancer and over representation of HPV 31 in high-grade dysplasia, according to a recent study.
The study is published in the June 2010 issue of the American Journal of Obstetrics and Gynecology, and describes the prevalence of cervical disease and human papillomavirus (HPV) in remote villages of Guyana.
The article, which is co-authored by Dr. Neil Quigley, vice president of clinical research services at Molecular Pathology Laboratory Network, Inc., presents results from a retrospective analysis of a clinical cervical cancer screening and treatment program where 2,250 women underwent cytologic screening and 1,423 women were screened for HPV. HPV genotyping was performed in 45 women with high-grade dysplasia and in 9 women with cervical carcinoma.
Invasive cervical carcinoma was found in 0.80% of the women, cervical intraepithelial neoplasia II and III in 5.07%, and a high-risk HPV infection rate in 19.3%, all of which peaked between the ages of 20-30 years. Sixteen genotypes were detected in women with high-grade dysplasia or cancer: HPV 31, 25.0%; HPV 16, 22.7%; HPV 18, 13.6%. The rate of HPV 16 and 18 in cervical cancer was 55.50%.
For information about HPV testing offered by MPLN, contact a technical service specialist at 800-932-2934.
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