Molecular Pathology Laboratory Network

Molecular characterization of T-cell receptor gene rearrangements and immunoglobulin heavy and light chain gene rearrangement detection is accomplished with reliable and robust tests for identifying clonal T-cell and B-cell populations found in a variety of cutaneous lymphoproliferative disorders.

While the demonstration of a clonal T/B cell population is not necessarily reflective of a truly pathologic process, positive results, interpreted in the context of all laboratory findings, can lend support to the diagnosis of malignancy.

The ability to routinely perform these studies on formalin fixed paraffin embedded biopsy materials make these highly sensitive and specific tests very well suited for the evaluation of these conditions.

Test Information and Specimen Requirements

• B-cell Immunoglobulin Heavy Chain gene rearrangement »
• BCL2 t(14;18) gene rearrangement »
• T-cell Receptor Gamma gene rearrangement »
• Flow cytometry to support T-cell lymphomas »
• Chromosome analysis - solid tissue »

For more information about gene rearrangement analysis, contact one of our service specialists at 800-932-2943.

Immunohistochemistry markers useful in differential diagnosis, prognosis, selection and monitoring of therapy for Melanoma include:

• CAM 5.2
• HMB-45, melanoma associated marker
• Melanoma cocktail (HMB-45, MelanA)
• M elanoma associated marker / Mart-1
• S-100 protein
• Tyrosinase
• Vimentin

Journal Articles