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Minimal Residual Disease Testing |
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Detection of minimal residual disease is accomplished through quantitative PCR, a technology that can provide at least 100 to 1000 times greater sensitivity than FISH. Additional studies using gene sequencing also assist in determining acquired drug resistance as is the case in Gleevec®-resistant chronic myeloid leukemia.
Journal Articles
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Jones D, Kamel-Reid S, Bahler D, Dong H, Elenitoba-Johnson K, Press R, Quigley N, Rothberg P, Sabath D, Viswanatha D, Weck K, Zehnder J. (2009). Laboratory practice guidelines for detecting and reporting BCR-ABL drug resistance mutations in chronic myelogenous leukemia and acute lymphoblastic leukemia: a report of the Association for Molecular Pathology.J Mol Diagn 11(1):4-11. Epub 2008 Dec 18
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