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Case Studies

  • Elderly Female with Pancytopenia

    Posted on March 30 2017

    Elderly Female with Pancytopenia

    h/o lung CA s/p taxotere/carboplatin in 2012-13 

    WBC  2900, HGB 10.1 g/dL, hct 30.6 %,  MCV 97.0 fL;  plt 56 k; absolute neutrophils 1340, absolute lymphocytes 1200, absolute monocytes 300

    Bone marrow submitted

    Bone Marrow Aspirate

    Atypical Megakaryocyte - small and hypolobated

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  • Breast Implant-Associated Anaplastic Large Cell Lymphoma

    Posted on March 21 2016

    Implant-associated anaplastic large cell lymphomas represent an extremely rare but well-documented complication of prosthetic breast implants. When presenting as an isolated fluid effusion in the absence of extracapsular tissue invasion or mass lesions, these neoplasms have been associated with a uniquely favorable clinical course.

    Clinical History:

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  • Hemophagocytic Lymphohistiocytosis, Mechanisms of Disease, Diagnosis, and Laboratory Findings

    Posted on October 17 2014

    Pathology Top Pick

    Hemophagocytic Lymphohistiocytosis (HLH) is a potentially fatal hyperinflammatory disease caused by a hyperactive and dysregulated immune response. This persistent elevation of proinflammatory cytokines ultimately results in end organ dysfunction. Although multiple types of HLH have been described, HLH can be broadly classified into primary and secondary forms. Primary forms of HLH are uncommon, typically occur in children, and are associated with genetic abnormalities.…
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  • High-Risk HPV-Associated Anal Basaloid Squamous Carcinoma

    Posted on July 09 2014

    Case Study

    Accurate recognition of anal basaloid squamous cell carcinomas (problematically called cloacogentic or transitional in the past), especially their distinction from poorly differentiated adenocarcinoma, urothelial carcinoma and neuroendocrine (oat cell) carcinoma can be difficult. Tumors with this histology can arise in the high anal transition zone (ATZ), which can be difficult to anatomically distinguish from the low-rectum. Therefore, confirmation of this diagnosis requires…
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  • Pathologic Classification of Products of Conception and Utility of p57 and Aneuploidy

    Posted on June 24 2014

    Pathology Update

    Pathologic classification of products of conception that are obtained from patients with unexplained pregnancy loss contributes significantly to clinical management.  Distinction  of hydropic abortus, partial hydatidiform mole, and complete hydatidiform mole can be impossible when based on morphology alone, yet these entities have different risk for persistent gestational trophoblastic disease. The combination of paraffin immunohistochemistry for p57 protein…
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