Literature Reviews and Summaries by MPLN Pathologists
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Molecular Mutation Status Identifies Prognostically Significant Risk Groups in AML |
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Friday, 06 January 2012 11:34 |
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Cytogenetic characteristics are the most important prognostic features in AML; however, roughly half of AMLs are cytogenetically normal (CN AML). Beyond conventional karyotyping, AMLs might be further prognostically stratified by molecular analysis targeted to genes that include but are not limited to FLT3, C-KIT, N-RAS, NPM1, CEBPA, WT1, ASXL1, DNMT3A, MLL, IDH1, IDH2, and TET2. Unfavorable molecular features are known to include MLL mutation or FLT3 internal tandem duplications (ID) in the presence of wild-type NPM1 in CN AMLs and C-KIT mutation in core-binding factor mutated AMLs, those with t(8;21) or inv(16).
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Differentiating Breast Cancer Metastases from Sweat Gland Carcinomas |
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Wednesday, 04 January 2012 12:13 |
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Breast cancers metastasizes to the skin relatively often, where they problematically mimic primary cutaneous neoplasms both morphologically and immunohistochemically. Authors identified 12 cutaneous breast carcinoma metastases (including 11 ductal and one basal type carcinoma ) and 11 sweat gland carcinomas (including 5 eccrine, 3 microcystic and 3 porocarcinomas) which they immunohistochemically stained for mammaglobin, gross cystic disease fluid protein 15 (GCDFP-15), p63, basal cytokeratins CK5, CK14, and CK17, androgen receptor, and PAX5 protein expression.
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Extending Storage and Fixation Requirements for HER2 Testing |
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Wednesday, 04 January 2012 11:31 |
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ASCO/ CAP guidelines prescribe a standardized ischemic time of < one hour and a rigid window of formalin fixation time ranging from 6 to 48 hours in 10% neutral buffered formalin (NBF) but not any other fixatives for HER2 breast cancer testing.
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New Classification for Pulmonary Adenocarcinoma, Association with EGFR Mutations |
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Monday, 28 November 2011 00:00 |
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Leading international pulmonary societies have jointly proposed a new classification for pulmonary adenocarcinoma in order to address limitations of the 2004 WHO classification system, which does not address new, predictive roles for molecular testing in management of lung cancer patients.
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ALK Gene Copy and Amplification Frequency Increased in NSCLC |
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Monday, 21 November 2011 13:51 |
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For EGFR and ALK genes, the significance of respective mutations and translocations are clear, but the importance of gene copy number changes are not. Reporting in J Thorac Oncol. 2011;6: 21-27 senior author Edurne Arriola and coauthors investigate the relationship of ALK and EGFR gene status in pulmonary adenocarcinomas.
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