100 Cases of Mixed Phenotype Acute Leukemia Documented | Molecular Pathology Laboratory Network, Inc.

100 Cases of Mixed Phenotype Acute Leukemia Documented

Wednesday, 21 September 2011 13:20

Dr. Estella Matutes from Royal Marsden Hospital in London and multiple European coauthors applied stringent WHO 2008 criteria to define and determine if 100 cases of true, mixed-phenotype acute leukemia have characteristic clinical or genetic features.

Roughly 90% showed >10% blast staining for TdT. 20% were BCR-ABL positive and 8% demonstrated MLL rearrangement. Since adult age and positive BCR-ABL status were poor prognostic indicators, these patients may be considered for bone marrow transplantation. Using the newer, more restricted definition of true, mixed-phenotype acute leukemia, ALL therapy was more effective than AML therapy.

Matutes et al. (2011). Mixed-phenotype acute leukemia: clinical and laboratory features and outcome in 100 patients defined according to the WHO 2008 classification. Matutes, et al. Blood. 117(11):3163-317

Editorial. Guy E.Nichols MD, PhD.

MPLN offers Flow Cytometry and FISH testing for ALL. For more information about these tests contact a client service specialist at 800.932.2943.

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