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MPLN offers VENTANA SP263 PDL-1 by IHC


MPLN offers VENTANA SP263 PDL-1 by IHC
Posted on May 02, 2017 by J Seabrook

MPLN offers SP263 immunohistochemical testing for the assessment of the PD-L1 protein in formalin-fixed, paraffin-embedded tissue. PD-L1 expression level utilizing this clone has been associated with response to durvalumab (IMFINZI, AstraZeneca UK Limited). AstraZeneca recently gained FDA approval durvalumab and for its complementary diagnostic Ventana PD-L1.

Assessment of tumor PD-L1 protein levels may have prognostic and/or therapeutic significance in some cancer patients. Specifically, identifying PD-L1 expression on tumor cells may help determine which patients will most benefit from anti-PD-1/PD-L1 therapy.

The VENTANA PD-L1 (SP263) Rabbit Monoclonal Primary Antibody (VENTANA PD-L1 (SP263)) is a rabbit monoclonal primary antibody directed against the programmed deathligand1 (PD-L1) B7 homolog 1 (B7-H1, CD274). The antibody detects the extracellular domain of PD-L1 and produces membranous and/or cytoplasmic staining.

PD-1 by immunohistochemistry detects the immune regulatory molecule programmed death-1 (PD-1) and has utility in both hematopathology diagnostics and in cancer biology. The programmed death-1 (PD-1) protein is expressed by follicular helper T-cells, and is useful in the diagnosis of hematolymphoid malignancies such as angioimmunoblastic T-cell lymphoma (AITL). In addition, clinical evidence suggests that IHC staining of the PD-1/PD-L1 pathway may have prognostic and/or therapeutic significance in some cancer patients.

MPLN selected the Ventana SP263 antibody as it complements existing laboratory platform and automation and has a simple single numerical cutoff value making interpretation more robust.

Read more about PD-L1 testing

PD-L1 and PD-1 Immunohistochemistry

Order information for PD-L1

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