D2 40 Podoplanin
Test Code
I D2 40
Associations
lymphatic endothelial cells, lymphovascular neoplasms
Methodology
Immunohistochemistry
CPT Codes
88342 each marker
Turnaround Time
Less than 2 days
Specimen Requirements
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Surgical samples received in 10% neutral buffered formalin
Formalin fixed paraffin embedded tissue
Previously prepared pathology materials (slides,smears, blocks or other samples)
Send reports, history and differential diagnosis
Specimen Stability
Indefinitely at room temperature
Storage & Handling
Ship ambient. In extreme hot weather, ship with a cool pack.
Causes for Rejection
Inadequate fixation; Improper labeling
Description
Podoplanin is a transmembrane mucoprotein (38 kd)recognized by the D2-40 monoclonal antibody. Podoplanin is selectively expressed in lymphatic endothelium as well as lymphangiomas, Kaposi sarcomas and in a subset of angiosarcomas with probable lymphatic differentiation. Podoplanin has also been shown to be expressed in epithelioid mesotheliomas hemangioblastomas and seminomas.
References
- Kalof AN, Cooper K.(2009). D2-40 immunohistochemistry--so far! Adv Anat Pathol.16(1):62-4
- Raica M, Cimpean AM, Ribatti D. (2008). The role of podoplanin in tumor progression and metastasis.Anticancer Res. 28(5B):2997-3006.
