Chromosome Analysis Constitutional Tissues
Test Code
CYTO TC
Test Synonyms
Chromosome analysis, cytogenetic analysis, karyotyping
Associations
POC, chorionic villus, fetal tissue, skin biopsy
Methodology
Analysis of cultured cells using G-bandings
CPT Codes
CPT codes by report:
88233 – Culture initiation
88262 – Chromosome analysis
88280 - Chromosome analysis, additional karyotype
88291 – Interpretation and report
88233 – Culture initiation
88262 – Chromosome analysis
88280 - Chromosome analysis, additional karyotype
88291 – Interpretation and report
Turnaround Time
7-10 days
Specimen Requirements
- Tissue from product of conception (fetal)
- 1 cm^3 skin biopsy
Specimen Stability
Stable for 48 hours at 18-25°C
Storage & Handling
Causes for Rejection
Specimen exposed to extreme temperature; Insufficient number of cells; Specimen exposed to formalin or other fixative
Reference Range
See report
Description
Solid tissue specimens largely include fetal and neonatal deaths or spontaneous abortions where a chromosome abnormality is suspected, or abortus material for confirmation of a chromosome abnormality. Also referred to as solid tissue, specimens are skin biopsies from patients with suspected inborn errors of metabolism where cells are grown primarily for enzymatic assay, or from patients with known or suspected chromosome mosaicism.
References
- Rooney D. (2001). Human Cytogenetics: constitutional analysis. 3rd edition, 81.
