trisomy 21
Test Code
F T21
Test Synonyms
+21, CEP 21
Associations
Down syndrome
Methodology
Fluorescence in situ Hybridization (FISH)
CPT Codes
Please contact a client service specialist at 800.932.2943
Turnaround Time
3 days
Specimen Requirements
- 2.0 mL (min. 1.0 mL) peripheral blood in sodium heparin preferred, EDTA accepted
- 5 mm^3 fresh tissue in MPLN RPMI media
Specimen Stability
- Peripheral blood stable at 4-25°C for 72 hours
- Fresh tissue stable at 2-8°C for 72 hours
Storage & Handling
- Peripheral blood, Ship with cool pack (refrigerated).
- Fresh tissue, ship in a Styrofoam container with an cool/refrigerated pack. (Do not allow cool/refrigerated pack to directly contact sample.)
Causes for Rejection
Clotted specimen; Specimen exposed to extreme temperature; Anticoagulant toxic to cells; Insufficient number of cells
Reference Range
See report
Description
An extra copy of chromosome 21 is the cause of Down syndrome. An increase risk is seen with the increase in maternal age.
References
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