Factor II Prothrombin G20210A
Test Code
F2PRO
Methodology
Invader® Assay System
CPT Codes
83891 – Molecular isolation
83892 – Enzymatic digestion
83896 x5 – Nucleic acid probe, each
83903 x1 – Mutation scan
83908 – Amplification each sequence
83912 – Interpretation and report
83892 – Enzymatic digestion
83896 x5 – Nucleic acid probe, each
83903 x1 – Mutation scan
83908 – Amplification each sequence
83912 – Interpretation and report
Turnaround Time
2-3 days
Specimen Requirements
5.0 mL (min. 3.0 mL) whole blood EDTA, ACD acceptable
Specimen Stability
Storage & Handling
Causes for Rejection
Clotted specimen; Specimen exposed to extreme temperature; Anticoagulant toxic to cells; Insufficient number of cells
Reference Range
See report.
Description
This test is used to assist with the evaluation of patients with hypercoagulability, including those with a (family) history of deep vein thrombosis or pulmonary embolism.
References
- Varga EA and Moll S. (2006). Prothrombin 20210 mutation (factor II mutation). Circulation 110: 15-18.
- Spector EB et al. (2005). Technical standards and guidelines: Venous thromboembolism (Factor v leiden and prothrombin 20210G>A testing): A disease-specific supplement to the standards and guidelines for clinical genetics laboratories. Genet Med. 7:444-453.
- Nagy PL et al. (2004). Molecular diagnosis of hypercoagulable states. Lab Med 4:214-222.
Trademarks
Invader is a registered trademark of Third Wave Technologies, Inc., a wholly owned subsidiary of Hologic, Inc.
