I HER2 or I HER2 TC
PATHWAY (4B5), Immuno, Immunohistochemistry, Immunoperoxidase
Breast cancer, Herceptin
88360 – Morphometric analysis, tumor immunohistochemstry
Formalin fixed paraffin embedded tissue block
Ship blocks at ambient temperature.
Improper specimen labeling; Insufficient sample; Inadequate fixation and/or processing
Normal breast tissues may produce positive reactivity scoring 1+ intensity, as will kidney, uterus and epithelium of the colon, stomach and small intestine. Normal tissues producing 2+ to 3+ staining intensity include esophageal epithelia, Langerhans cells, pituitary endocrine cells, prostate and squamous epithelia of tonsil.
Click here for Ventana Interpretive Guide
Ventana Medical Systems, Inc.'s (Ventana) PATHWAY anti-HER-2/neu (4B5) Rabbit Monoclonal Primary Antibody (PATHWAY HER2(4B5))is a rabbit monoclonal antibody intended for laboratory use for the semi-quantitative detection of HER2 antigen in sections of formalin-fixed, paraffin-embedded normal and neoplastic tissue on a Ventana automated immunohistochemistry slide staining device. It is indicated as an aid in the assessment of breast cancer patients for whom Herceptin® treatment is considered.
In a fraction of patients with breast cancer, the HER2 protein is over expressed as part of the process of malignant transformation and tumor progression. Over expression of the HER2 protein on the surface of breast cancer cells suggest that it could be a target for antibody therapy, Herceptin (Trastuzumab).
HercepTest is a registered trademark of Genentech, Inc.