Molecular Pathology Laboratory Network

I ERCC1

oxaliplatin response in colorectal cancer

Immunohistochemistry

88342 each marker

Less than 2 days

• Surgical samples received in 10% neutral buffered formalin
• Formalin fixed paraffin embedded tissue
• Previously prepared pathology materials (slides,smears, blocks or other samples)

Send reports, history and differential diagnosis.

Indefinitely at room temperature

Ship ambient. In extreme hot weather, ship with a cool pack.

Inadequate fixation; Improper labeling

The mammalian ERCC1 (Excision Repair Cross Complementing) polypeptide is required for nucleotide excision repair (NER) of damaged DNA and is homologous to Saccharomyces cerevisiae RAD10, which functions in repair and mitotic intrachromosomal recombination. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells XPG cleaves 3' of the DNA lesion while the ERCC1 XPF complex makes the 5'incision. Elevated levels of ERCC1 have also been reported in Cisplatin resistant cells.

1. C. T. Lan et al. (2009). C.ERCC-1 (E) expression and its effect on survival in patients (pts) receiving concurrent cisplatin (C)and radiation (R) for locally advanced head and neck cancer (HNC). Journal of Clinical Oncology, 27:15S
2. Carvalho L et al.(2009 ). ERCC1 and RRM1 genes in lung cancer. Rev Port Pneumol.15(4):683-96