p16
Test Code
I P16
Test Synonyms
Tumor suppressor gene, Cyclin-dependent kinase inhibitor 2A, CDKN2A, p16Ink4A
Associations
Head and Neck squamous cancer, myeloma, bladder cancer, cervical cancer. gastric cancer
Methodology
Immunohistochemistry
CPT Codes
88342 each marker
Turnaround Time
Less than 2 days
Specimen Requirements
- Surgical samples received in 10% neutral buffered formalin
- Formalin fixed paraffin embedded tissue
- Previously prepared pathology materials (slides,smears, blocks or other samples)
Specimen Stability
Indefinitely at room temperature
Storage & Handling
Ship ambient. In extreme hot weather, ship with a cool pack.
Causes for Rejection
Inadequate fixation; Improper labeling
Related Content
p16ink4a, clone E6H4
Description
P16 plays an important role in regulating the cell cycle, and mutations in p16 increase the risk of developing a variety of cancers.
References
- Romagosa C et al.(2011.p16Ink4a overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors.Oncogene 30:2087-2097
- Kian Ang K et al. (2010).Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer. N Engl J Med 363:24-35.
- Lewis J,S et al. (2010). p16 Positive Oropharyngeal Squamous Cell Carcinoma: An Entity With a Favorable Prognosis Regardless of Tumor HPV Status. Am J Surg Pathol 34:1088–1096