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Fluorescence in situ hybridization (FISH)

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Acute Lymphoblastic Leukemia (ALL) Adult Profile ^Featured

Test CodeF AALL

AssociationsAcute lymphoblastic leukemia (ALL)

MethodologyFluorescence in situ Hybridization (FISH)

Acute Lymphoblastic Leukemia (ALL) Pediatric Profile ^Featured

Test CodeF PALL

AssociationsAcute lymphoblastic leukemia (ALL)

MethodologyFluorescence in situ Hybridization (FISH)

ALK 2p23 gene rearrangement ^Featured

Test CodeF ALK

AssociationsNSCLC with ALK gene rearrangements can now be treated with Xalkori (crizotinib), FDA approved for late stage locally advanced or metastatic NSCLC.

MethodologyFluorescence in situ Hybridization (FISH)

AML1/ETO t(8;21)

Test CodeF AML ETO

AssociationsAcute myelogenous leukemia, AML(M2)

MethodologyFluorescence in situ Hybridization (FISH)

API2/MALT1 t(11;18)

Test CodeF API MALT

AssociationsMALT lymphoma, Non-Hodgkin (NHL), Extranodal marginal zone B-cell lymphoma

MethodologyFluorescence in situ Hybridization (FISH)

ATM deletion 11q22.3

Test CodeF ATM

AssociationsChronic lymphocyctic leukemia (CLL)

MethodologyFluorescence in situ Hybridization (FISH)

BCL1 IGH/CCND1 t(11;14)

Test CodeF BCL1

AssociationsB-cell lymphoma, Non-Hodgkin lymphoma (NHL), Mantle cell lymphoma (MCL)

MethodologyFluorescence in situ Hybridization (FISH)

BCL2 IGH/BCL2 t(14;18)

Test CodeF BCL2

AssociationsB-cell lymphoma (BCL), Non-Hodgkin lymphoma (NHL), Follicular lymphoma (FCL)

MethodologyFluorescence in situ Hybridization (FISH)

BCL6 3q27 Rearrangement

Test CodeF BCL6

AssociationsB-cell lymphoma, Non-Hodgkin lymphoma (NHL), Diffuse large B cell, Follicular lymphoma

MethodologyFluorescence in situ Hybridization (FISH)

BCR/ABL+9q34, t(9;22)

Test CodeF BCR ABL

AssociationsChronic Myelogenous Leukemia (CML), Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML), Myelodsplastic Syndrome (MDS), Myeloproliferative Disorder (MPD)

MethodologyFluorescence in situ Hybridization (FISH)

Burkitt/Large B-cell Lymphoma Profile

Test CodeF BURKITT

MethodologyFluorescence in situ Hybridization (FISH)

C MYC 8q24 Rearrangement

Test CodeF CMYC

AssociationsLymphoma, Burkitt, Diffuse large B-cell, Solid tumors, Breast and prostate cancer

MethodologyFluorescence in situ Hybridization (FISH)

CBFB t(16;16), inv(16)

Test CodeF CBFB

AssociationsAcute myelogenous leukemia (AML), Eosinophilia M4eo

MethodologyFluorescence in situ Hybridization (FISH)

CEP 7 -7/7q31-

Test CodeF CEP7

AssociationsAcute myelogenous leukemia (AML), Myelodysplastic syndrome (MDS)

MethodologyFluorescence in situ Hybridization (FISH)

Chronic Lymphocytic Leukemia (CLL) Profile ^Featured

Test CodeF CLL

AssociationsChronic Lymphocytic Leukemia(CLL)

MethodologyFluorescence in situ Hybridization (FISH)

Deletion 13q14.3

Test CodeF D1314

AssociationsChronic lymphocytic leukemia (CLL), Non-Hodgkin lymphoma (NHL), Mantle cell lymphoma (MCL), Myeloma

MethodologyFluorescence in situ Hybridization (FISH)

Deletion 20q12

Test CodeF D20

AssociationsAcute myeloid leukemia (AML), myelodysplastic syndrome (MDS), myeloproliferative disorder (MPD)

MethodologyFluorescence in situ Hybridization (FISH)

EGFR 7p12 Amplification

Test CodeF EGFR

AssociationsBreast, lung and colon cancer

MethodologyFluorescence in situ Hybridization (FISH)

EGR1 -5/5q-

Test CodeF EGR1

Associations5q- syndrome, Myelodysplasia (MDS), Myeloproliferative disease (MPD), Acute myelogenous leukemia (AML)

MethodologyFluorescence in situ Hybridization (FISH)

EWSR1 22q12 Rearrangement Ewing Sarcoma

Test CodeF EWSR1

AssociationsEwing sarcoma

MethodologyFluorescence in situ Hybridization (FISH)

FIP1L1/PDGFRA 4q12 Rearrangement

Test CodeF 4Q12

AssociationsHypereosinophilia, Mast cell

MethodologyFluorescence in situ Hybridization (FISH)

HER2 Gastric by FISH ^Featured

Test CodeF HER2 GA

AssociationsGastric and gastroesophageal junction (GEJC)cancer

MethodologyFluorescence in situ Hybridization (FISH)

HER2/neu PathVysion®

Test CodeF HER2

AssociationsBreast cancer

MethodologyFluorescence in situ Hybridization (FISH)

IGH 14q32 Rearrangement

Test CodeF IGH

AssociationsNon-Hodgkin lymphoma, Myeloma

MethodologyFluorescence in situ Hybridization (FISH)

IGH/FGFR3 t(4;14)

Test CodeF FGFR3

AssociationsMyeloma, monoclonal gammopathy (MGUS)

MethodologyFluorescence in situ Hybridization (FISH)

IGH/MAF t(14;16)

Test CodeF IGH MAF

AssociationsMyeloma, MGUS

MethodologyFluorescence in situ Hybridization (FISH)

IGH/MALT1 t(14;18)

Test CodeF IGH MALT

AssociationsMALT lymphoma

MethodologyFluorescence in situ Hybridization (FISH)

IGH/MYC CEP 8 t(8;14)

Test CodeF IGH MYC

AssociationsBurkitt lymphoma

MethodologyFluorescence in situ Hybridization (FISH)

MALT1 18q21

Test CodeF MALT

AssociationsMucosa-associated lymphoid tissue (MALT lymphoma)

MethodologyFluorescence in situ Hybridization (FISH)

MLL 11q23

Test CodeF MLL

AssociationsAcute myelogenous leukemia (AML), Acute lymphoblastic leukemia (ALL), HOX gene

MethodologyFluorescence in situ Hybridization (FISH)

MYB deletion 6

Test CodeF MYB

AssociationsChronic lymphocytic leukemia (CLL), Childhood acute lymphoblastic leukemia (ALL), B-cell small lymphocytic lymphoma (SLL), Plasma cell myeloma

MethodologyFluorescence in situ Hybridization (FISH)

Myelodsyplastic Syndrome Profile ^Featured

Test CodeF MDS

AssociationsMyelodsyplasia (MDS)

MethodologyFluorescence in situ Hybridization (FISH)

Myeloma Profile ^Featured

Test CodeF MM

AssociationsMultiple Myeloma

MethodologyFluorescence in situ Hybridization (FISH) F MM will be auto reflexed to F FGFR3 t(4;14) and F IGH MAF t(14;16) when IGH is rearranged with a locus other than BCL1