Warfarin Sensitivity Testing
Test Code
WARF*
Test Synonyms
WARF; CYP2C9 and VKORC1 allele testing
Associations
Cytochrome P450 (CYP2C9 or 2C9), Coumadin
Methodology
Verigene® Warfarin Metabolism Nucleic Acid Test (IVD)
CPT Codes
Please contact a client service specialist at 800.932.2943
Turnaround Time
2-3 days
Specimen Requirements
1.0 mL EDTA blood
Specimen Stability
Stable 4°C for up to 10 days
Storage & Handling
Ship with cool/refrigerated pack (Do not allow cool/refrigerated pack to directly contact sample)
Causes for Rejection
Less than 1.0 mL blood; Improper specimen labeling
Reference Range
CYP2C9*2 allele detected/not detected
CYP2C9*3 allele detected/not detected
VKORC1 1173C>T allele detected/not detected
CYP2C9*3 allele detected/not detected
VKORC1 1173C>T allele detected/not detected
Related Content
Description
Intended for the detection and genotyping of the *2 and *3 alleles of the CYP2C9 gene and a single polymorphism (1173C>T) in the VKORC1 gene as an aid in the identification of patients at risk for increased warfarin sensitivity.
References
- McClain MR et al. (2008). A rapid ACCE review of CYP2C9 and VKORC1 allele testing to inform warfarin dosing in adults at elevated risk for thrombotic events to avoid serious bleeding. Genet Med. 10:89-98.
- Schwarz UI. (2008). Genetic determinants of response to warfarin during initial anticoagulation. NEJM. 358:999-1008.