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Pathology & Immunohistochemistry | Flow Cytometry | Cancer Cytogenetics | FISH
Gene Rearrangement |Genotyping | Minimal residual Disease | Mutation analysis
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Pathology & immunohistochemistry
Bone marrow pathology evaluation »
Surgical pathology consultationSurgical pathology professional
Breast markers:
Breast 2 profile: Cytokeratin 5, p63, CK8/18
Cathepsin D
Cell cycle analysis; DNA Ploidy and S Phase
E-Cadherin epithelial cell, ductal-type
Estrogen / progesterone receptors »Gross cystic disease fluid protein 15 (BRST-2 protein)
Herceptest (HER2) »
HER2/neu PathVysion® by FISH»
Ki67 »
p53Complete list of IHC markers available for:
Breast, colon, prostate, thyroid and other cancers
Dermatopathology
Hematopathology
Infectious agents
NeuropathologySpecialty markers:
Cytokeratins, endothelial, mesothelioma,
microsatellite instability,
ProEx™ C biomarkerCellSearch™ circulating tumor cells
Comprehensive Leukemia / and or Lymphoma evaluation»
Targeted evaluation:Myeloid or Lymphocyte screen »
ZAP 70 »
Bronchoalveolar lavage (CD3, CD4, CD8, CD16, CD4:8 ratio) »
Cell cycle analysis; DNA Ploidy and S phase»Leukocyte adhesion deficiency (CD11a, CD11b, CD11c, CD18) »
Lymphocyte analysis (T-cell subsets plus CD19, CD56) »Paroxysmal nocturnal hemoglobinuria (CD55, CD59)»
T-cell subsets (Absolute CD4, CD3, CD4, CD8, CD4:CD8 ratio) »
Leukoreduced WBC count »
Chromosome analysis - bone marrow
Chromosome analysis - unstimulated peripheral blood
Chromosome analysis - solid tissue
Acute lymphoblastic leukemia Adult
Acute Lymphoblastic Leukemia (Adult) profile includes:
BCR/ABL 9q34 t(9;22), MLL 11q23, MYB del6q, TEL/AML1 ES t(12;21)
Acute lymphoblastic leukemia Pediatric
Acute Lymphoblastic Leukemia (Pediatric) profile includes:
BCR/ABL 9q34 t(9;22), MLL 11q23, +4, +10, TEL/AML1 ES t(12;21)
Acute myeloid leukemia
Anaplastic Large cell lymphoma
Burkitt lymphoma
C MYC 8q24
IGH/MYC, CEP 8 t(8;14)
Chronic lymphocytic leukemia
Chronic Lymphocytic Leukemia profile includes:
p53 del 17p13.1, ATM del 11q22.3, del 13q14.3/ del 13q34, +12, MYB del 6q
Additonal probes include:
Chronic myeloproliferative disorder
Follicular cell lymphoma
MALT lymphoma
IGH/MALT1 t(14;18)
MALT1 18q21
Mantle cell lymphoma
Myelodysplasia
Myeloma
+5 / +9 / +15, del 13q14.3, p53 del 17p13.1, IGH 14q32
Additional probes include:
IGH/FGFR3 t(4;14)
IGH/MAF t(14;16)
trisomy 3
trisomy 7
Myeloproliferative disorder
Non Hodgkins lymphoma
C MYC 8q24
IGH t(14q32)
IGH/MALT1 t(14;18)
IGH/MYC, CEP8 t (8;14)
MALT1 t(18q21)
trisomy 12
Pediatric Oncology
Acute Lymphoblastic Leukemia (Pediatric) profile »
N-MYC 2p24.1 neuroblastomaTransplantation Bone marrow
X/Y post sex-mismatch transplantation
Fluorescence in situ hybridization (FISH) solid tumors
C MYC 8q24 .12 breast, prostate and other cancer
EGFR/CEP7 (HER1/erb-B1) breast, lung and colon cancer
EWSR1 22q12 Ewing’s sarcoma
HER2-neu PathVysion® breast cancer »
N-MYC 2p24.1 neuroblastoma
Oligodendroglioma del 1p36/del 19q13 glioma
p53 del 17p13.1
PTEN/CEP10 del 10q23
SYT 18q11.2 synovial sarcoma
UroVysion® : +3 /+ 7 /+17 / del 9p21 bladder cancer
Molecular Oncology
B-cell Immunoglobulin Heavy Chain gene rearrangement »
Minimal residual disease: Quantitative PCR
ABL Kinase mutation and Gleevec® resistance»
FLT3 mutationis in acute myelogenous leukemia»
JAK2 V617F mutation in Ph.neg.chronic myeloproliferative disorders»
Molecular Genetics
Cystic fibrosis 32 mutation analysis panel by PCR (diagnostic and carrier»
Cystic fibrosis intron 8 5T/7T/9T by PCR»
Factor II (Prothrombin) G20210A mutation »
Factor V (Leiden) G1691A/R506Q mutation »
Friedreich ataxia mutation gene sequencing »
Methylenetetrahydrofolate reductase mutation C677T mutation »
MTHFR C667T and A1298C mutations »
Plasminogen Activator Inhibitor-1 4G/5G polymorphism »
Tests performed at Ascendant Medical Laboratory »
Maternal serum screening and Quad screen
Alpha-feto protein
Obstetric panel
Prenatal Diagnostics
Cytogenetics - constitutional chromosome analysis
Chorionic villus
Products of conception
Fluorescence in situ hybridization (FISH) - constitutional
AneuVysion®: +13 /+18 /+21 /X/Y »
Angelman syndrome del 15q11q13 »
Cri-du-Chat syndrome deletion 5p15.2
DiGeorge/ Velo-Cardio-Facial syndrome deletion 22q11.2
Kallmann syndrome del KAL1(Xp22.3)
Miller-Dieker syndrome / Lissencephaly LIS1/RARA del 17p13.3
Phelan-McDermid syndrome N25/ARSA del 22q13.3
Prader-Willi/Angelman del 15q11-q13
Smith-Magenis syndrome del 17p11.2
SRY/CEP X del Yp11.3
Steroid Sulfatase deficiency STS/CEP X for X-linked ichthyosis
TelVysion®: subtelomeres »
trisomy 7trisomy 21
Wolf-Hirschhorn syndrome del 4p16.3
Williams syndrome del 7q11.23
Infectious Diseases
Chlamydia trachomatis qualitative by Aptima COMBO® 2 »
Hepatitis C virus genotyping by invader system
Hepatitis C virus RNA qualitative by real-time PCR »
Hepatitis C virus RNA quantitative by real-time PCR »
Herpes simplex virus Type 1 and 2 qualitative by real-time PCR
Human immunodeficiency virus quantitation by PCR
Human immunodeficiency virus ultrasensitive quantitation by PCR
Human papillomavirus high risk by hybrid capture® II »
Human papillomavirus genotyping »Neisseria gonorrhoeae qualitative by Aptima COMBO® 2 »
Viral Profile (CMV, EBV, ENT, Parvovirus B-19, Adenovirus)