Ki67 (Clone:Mib-1)

Ki67

Test Synonym:

Immuno, Immunocytochemistry, Immunoperoxidase, IHC

Test Synonym:

88342 – Immunohistochemistry

Turnaround Time:

3 days

Methodology:

Immunocytochemistry

Specimen Requirements:

Formalin fixed paraffin-embedded tissue block

Causes for Rejection:

Improper specimen labeling; insufficient sample; inadequate fixation or processing

Specimen Stability:

Indefinite at room temperature

Storage and Handling:

Ship individually packaged blocks at ambient temperature; include ice pack if external temperatures exceeds 55° C.

Reference Range:

The Ki67 antigen is expressed during all active phases of cellular proliferation.

Indication:

Useful in monitoring the growth of normal and neoplastic cells, this valuable marker is often used as part of a panel of antibodies in differential tumor diagnosis. 

References:

1. Gerdes J, Becker MH, Key G, Cattoretti G (1992). Immunohistological detection of tumor growth fraction (Ki-67 antigen) in formalin-fixed and routinely  processed tissues.  J Pathol 168:85-6.
2. Scholzen T, Gerdes J. (2000). The Ki-67 protein: from the known and the unknown [review].  J Cell Physiol 182:311-22.