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Abc-Z FISH, interphase

Test Code

See associations below

Test Synonyms

Fluorescent in situ Hybridization, FISH

Associations
Description Test Code
Adult Acute Lymphoblastic Leukemia Panel
[t(9;22), t(12;21), MLL(KMT2A)]
F AALL
ALK 2p23 rearrangment FP ALK
AML1(RUNX1)/ETO(RUNXT1), t(8;21) F AML ETO
API2/MALT1, t(11;18) F API MALT
ATM/CEP 11 deletion 11q22.3 F ATM
BCL6 3q27 rearrangement F BCL6; FP BCL6
BCR/ABL1 t(9;22) F BCR ABL
Bladder Cancer +3,+7,+17,9p21- F URO
Burkitt/ "Double Hit" Large B-cell Lymphoma Panel
[C-MYC, BCL2, BCL6]
F BURKITT; FP BURKITT
CBFB t(16;16), inv(16) F CBFB
CEP 7 -7/7q31 F CEP7
Chronic Lymphoblastic Leukemia Panel [MYB(6q23),
ATM(11q22.3), +12, DLEU1(13q14.3), TP53(17p13)]
F CLL
C MYC 8q24 rearrangement F CMYC; FP CMYC
Deletion 7q22 F 7q
Deletion 13q14.3 F D1314
Deletion 20q12 D D20
EGR1 5q deletion, monosomy 5 F EGR1
FIPIL1/PDGFRα 4q12 gene rearrangement F 4Q12
HER2/neu breast cancer FP HER2
HER2/neu ALT FP ALT HER2
HER2/neu gastric cancer FP HER2 GA
IGH 14q32 rearrangement F IGH; FP IGH
IGH/BCL1(CCND1) t(11;14) F BCL1; FP BCL1
IGH/BCL2 t(14;18) F BCL2; FP BCL2
IGH/FGFR3 t(4;14) F FGFR3
IGH/MAF t(14;16) F IGH MAF
IGH/MALT1 (t(14;18) F IGH MALT; FP IGH MALT
IGH/MYC t(8;14) F IGH MYC; FP IGH MYC
MALT1 18q21 gene rearrangement F MALT; FP MALT
MLL(KM2A) 11q23 gene rearrangement F MLL
Molar Pregnancy +13,+18,+21,X,Y FP ANEU
MYB 6q deletion F MYB
Myelodysplasia Panel [-5/5q-, -7/7q-, +8, 20q-] F MDS
Myeloproliferative Panel [+8, t(9;22), 13q-, 20q-] M MPD
Oligodendroglioma, deletion 1p-, 19q- FP GLI
Oligodendroglioma, 7p amp FP EGFR
Oligodendroglioma, 1p-;19q-; 7p amp FP GLIO MAP
PDGFRβ Gene Rearrangement F PDGFRB
Plasma Cell Neoplasms Panel
[1p-, 1q+ +5, +9, t(11;14), 13q-, +15, 17p-]
F MM
PML/RARA t(15;17) F PML RARA
TP53 17p13 deletion F P53
ROS1 6q22.1 rearrangement FP ROS1
Trisomy 5, 9,15 F T5T9T15
Trisomy 8 F T8
TEL(ETV6)/AML1(RUNX1) t(12;21) F TEL AML1

 

Methodology

Fluorescence in situ Hybridization (FISH)

Turnaround Time

3-5 days

Specimen Requirements

2.0 mL (min. 1.0 mL) peripheral blood in sodium heparin preferred, EDTA accepted
1.0 mL (min. 0.5 mL) bone marrow in sodium heparin preferred, EDTA accepted
5 mm^3 fresh tissue in MPLN RPMI media
3.0 mL (min. 2.0 mL) FNA in MPLN RPMI media
10% neutral buffered formalin fixed paraffin embedded tissue

Specimen Stability
Peripheral blood and bone marrow stable at 18-25°C for 72 hours
Fresh tissue or FNA at 2-8°C stable for 72 hours
Storage & Handling

Whole blood and bone marrow, ship ambient
Fresh tissue, FNA or paraffin embedded tissue, ship in a Styrofoam container with a cool/refrigerated pack (Do not allow cool pack to directly contact sample.)

Causes for Rejection

Clotted specimen; Specimen exposed to extreme temperature; Anticoagulant toxic to cells; Insufficient number of cells; Improper fixative

Reference Range

See report.

Description

Fluorescence in situ Hybridization (FISH) performed on interphase cells.