Anaplastic large cell Lymphoma
Surgical samples received in 10% neutral buffered formalin
Formalin fixed paraffin embedded tissue
Previously prepared pathology materials (slides,smears, blocks or other samples)
Send reports, history and differential diagnosis
Ship ambient. In extreme hot weather, ship with a cool pack.
Inadequate fixation; Improper labeling
Anaplastic lymphoma kinase-1 recognizes a formalin resistant epitope in both the p80 protein, identified as a hybrid of the anaplastic lymphoma kinase (ALK) protein and the nucleophosmin (NPM) protein and the 200 kD normal ALK proteins. ALK-1 may also recognize any ALK protein chimeric produced as a result of variant translocations involving the ALK gene on chromosome 2.
ALK-1 recognizes varying degrees of ALK expression in both the cytoplasm and nucleus of anaplastic lymphoma cells. ALK protein expression is substantially specific for anaplastic lymphomas, except for weak expression in some normal cells in the central nervous system including neurons, glial cells and endothelial cells. ALK expression may also be seen in inflammatory myofibroblastic tumors and rare rhabdomyosarcomas.