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B-cell Lymphoma Markers by Immunohistochemistry (IHC)

Test Code

See associations below

Associations
Test Code Description
I ANXA1 Annexin A1, hairy cell, B-cell lymphoma
I BCL 2 BCL2 follicular lymphoma, apoptosis
I BCL 6 BCL6 follicle center B-cells
I CD20 CD20 pan B-cell
I CD23 CD23 activated B-cell 125
I CD79a CD79a B-cell, plasma cells
I CD10 CD10, Common ALL antigen
I CYCLIN Cyclin D1/PRAD1, mantle cell lymphoma
I MUM1 MUM1, multiple myeloma oncogene
I PAX 5 PAX-5, B-cell transcription factor
  * Performed at affiliate laboratory

 

Methodology

Immunohistochemistry
Technical component (TC) available for all markers

Turnaround Time

2 days

Specimen Requirements
  • Formalin fixed tissue
  • Formalin fixed paraffin embedded tissue (preferred)
Specimen Stability
Indefinitely at room temperature
Storage & Handling

Ship ambient. In extreme hot weather, ship with a cool pack.

Causes for Rejection

Inadequate fixation; Improper labeling

Reference Range

Marker and tissue specific

Description

Results are reviewed by a board-certified pathologist to determine if tissues are positive or negative for the marker. These results may be used to assist in determining appropriate patient therapy or treatment.

Immunohistochemistry (IHC) combines the principles of histochemistry with the high degree of molecular specificity of the antibody-antigen reaction. The use of an enhanced-polymer detection system provides many benefits including increased sensitivity, fewer procedural steps as compared to conventional techniques, and a reduction in non-specific background staining. MPLN offers a range of markers by IHC including hematologic, tissue specific, infectious agents and proliferation antigens.

References
  1. Press M et al. (2002). Steroids. 67:799-813.
  2. Perttschuk et al. (1996). Cancer. 77:2514-15.
  3. Battifora et al. (1993). Appl Immunohistochem. 1:39-45.