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Bone Marrow Progenitors/Leukemia/Blastic Markers by Immunohistochemistry (IHC)

Test Code

See associations below

Associations
Test Code Description
I CD10 CD10, Common ALL antigen
I CD42b CD42b, Glycoprotein, GpIb, platelets, megakaryocytes
I CD68 CD68 macrophages
I CD34 CD34 endothelial, stem cells, stromal cells
I CD117 CD117 C-kit, (ckit) myeloid and mast cell
I GLYCPA Glycophorin-A
I MPO Myeloperoxidase
I TDT Terminal deoxynucleotidyl transferase
I VWF Von Willebrand factor VIII
  * Performed at affiliate laboratory
I CD99 Ewings sarcoma, PNET, ALL

 

Methodology

Immunohistochemistry
Technical component (TC) available for all markers

Turnaround Time

2 days

Specimen Requirements
  • Formalin fixed tissue
  • Formalin fixed paraffin embedded tissue (preferred)
Specimen Stability
Indefinitely at room temperature
Storage & Handling
  • Ship ambient.
  • In extreme hot weather, ship with a cool pack.
Causes for Rejection

Inadequate fixation; Improper labeling

Reference Range

Marker and tissue specific

Description

Results are reviewed by a board-certified pathologist to determine if tissues are positive or negative for the marker. These results may be used to assist in determining appropriate patient therapy or treatment.
Immunohistochemistry combines the principles of histochemistry with the high degree of molecular specificity of the antibody-antigen reaction. The use of an enhanced-polymer detection system provides many benefits including increased sensitivity, fewer procedural steps as compared to conventional techniques, and a reduction in non-specific background staining.
 


MPLN offers a range of markers by Immunohistochemistry including hematologic, tissue specific, infectious agents and proliferation antigens.

References
  1. Press M et al. (2002). Steroids. 67:799-813.
  2. Perttschuk et al. (1996). Cancer. 77:2514-15.
  3. Battifora et al. (1993). Appl Immunohistochem. 1:39-45.