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c-kit protein by IHC

Test Code

I CD117

Test Synonyms

CD117 antigen expression

Associations

myeloid, mast cells, gastrointestinal stromal tumors (GIST)

Gleevec (imatinib mesylate)

Methodology

Immunohistochemistry
Technical component (TC) available for all markers.

Turnaround Time

2 days

Specimen Requirements

Surgical samples received in 10% neutral buffered formalin
Formalin fixed paraffin embedded tissue
Previously prepared pathology materials (slides,smears, blocks or other samples)
Send reports, history and differential diagnosis

Specimen Stability
Indefinitely at room temperature
Storage & Handling

Ship ambient
In extreme hot weather, ship with a cool pack

Causes for Rejection

Inadequate fixation
Improper labeling

Reference Range

Marker and tissue specific

Description

Results are reviewed by a board-certified pathologist to determine if tissues are positive or negative for the marker. These results may be used to assist in determining appropriate patient therapy or treatment. Immunohistochemistry combines the principles of histochemistry with the high degree of molecular specificity of the antibody-antigen reaction. The use of an enhanced-polymer detection system provides many benefits, including increased sensitivity, fewer procedural steps as compared to conventional techniques, and a reduction in non-specific background staining. MPLN offers a range of markers by Immunohistochemistry including hematologic, tissue specific, infectious agents and proliferation antigens.

References
  1. Battifora et al. (1993). Appl Immunohistochem. 1:39-45.
  2. Perttschuk et al. (1996). Cancer. 77:2514-15.
  3. Press M et al. (2002). Steroids. 67:799-813.
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