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Keratin/Epithelial Markers by Immunohistochemistry (IHC)

Test Code

See associations below

Test Code Description
I CEA CEA carcinoembryonic antigen
I CDX2 CDX2 colorectal carcinoma
I CK5/6 Cytokeratinj 5/6, positive squamous, mesothelia
I CK7 Cytokeratin 7, 54kD
I CK HMW 34BE12, Cytokeratin high molecular weight
I CAM52 Cytokeratin 8 (CAM5.2)
I CK8/18 Cytokeratin 8/18
I CK20 Cytokeratin 20
I D2 40 D2-40, Podoplanin
I GCDFP15 Gross cystic disease fluid protein 15
I HEPAR1 Hepatocyte antigen (HEP-Par-1), liver
I RCC Renal cell carcinoma
I CK8 Cytokeratin 8, 35BH11
I CK19 Cytokeratin 19
I GALECT Galectin-3, thyroid neoplasm, anaplastic LCL
I THYRGLB Thyroglobulin
I TTF1 Thyroid transcription factor-1, lung, thyroid
I INHIB Inhibin, adrenal cortical, sex chord stromal
I PLAP Placental alkaline phosphatase, germ cell tumor



Technical component (TC) available for all markers

Turnaround Time

2 days

Specimen Requirements

Paraffin embedded tissue block
3 slides (3-5 uM) per marker on adhesion glass

Specimen Stability
Indefinitely at room temperature
Storage & Handling

Ship ambient. Protect from extreme temperature with an ice pack. Separate ice pack from specimen.

Causes for Rejection

Inadequate fixation; Improper labeling

Reference Range

Marker and tissue specific


Results are reviewed by a board-certified pathologist to determine if tissues are positive or negative for the marker. These results may be used to assist in determining appropriate patient therapy or treatment.
Immunohistochemistry combines the principles of histochemistry with the high degree of molecular specificity of the antibody-antigen reaction. The use of an enhanced-polymer detection system provides many benefits including increased sensitivity, fewer procedural steps as compared to conventional techniques, and a reduction in non-specific background staining.

MPLN offers a range of markers by Immunohistochemistry including hematologic, tissue specific, infectious agents and proliferation antigens.

  1. Press M et al. (2002). Steroids. 67:799-813.
  2. Perttschuk et al. (1996). Cancer. 77:2514-15.
  3. Battifora et al. (1993). Appl Immunohistochem. 1:39-45.