M KIT AML
KIT exon 8, or exon 17 mutation
Fragment analysis and sequencing
12-14 days
5 mL ( min.3 mL) whole blood or 3 mL (min.1 mL) bone marrow EDTA
Ship at ambient temperature, cool in summer. (Do not allow cool/refrigerated pack to directly contact sample.)
Serum or plasma; Frozen or clotted specimens; Specimens collected in anticoagulants other than EDTA; Severely hemolyzed specimens.
Detected − KIT exon 8 or 17 mutation detected
Detects mutations in exon 17 in specimens with at least 30% AML cells carrying the mutation
Detects mutations in exon 8 in specimens with at least 5% AML cells carrying the mutation
Associated with less favorable outcome. TKIs may be useful in conjunction with standard chemotherapy