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Lung Markers by Immunohistochemistry (IHC)

Test Code

See associations below

Associations
Test Code Description
I AE1/AE3 cytokeratin cocktail, PAN(AE1/AE3)
I BER EP4 epithelial antigen
I CEA carcinoembryonic antigen
I CD56 NK cells
I CDX2 CDX2
I CHROGRAN chromogranin A
I CK HMW Cytokeratin high molecular weight; 34BE12
I CK5/6 Cytokeratin 5/6, squamous, mesothelial
I CK7 Cytokeratin 7, 54kD
I CK19* cytokeratin 19
I CK20 Cytokeratin 20
I NF* neurofilament
I P53 p53 tumor suppressor gene protein
I P63NU p63 nuclear, tumor suppressor gene protein
I SYNPTP Synaptophysin
I TTF1 Thyroid Transcription Factor-1
I WT1 Wilm's tumor

 

Methodology

Immunohistochemistry
* performed by affiliate laboratory

Technical component (TC) available for all markers

Turnaround Time

2 days

Specimen Requirements
  • Surgical samples received in 10% neutral buffered formalin
  • Formalin fixed paraffin embedded tissue
  • Previously prepared pathology materials (slides,smears, blocks or other samples)

Send reports, history and differential diagnosis

Specimen Stability
Indefinitely at room temperature
Storage & Handling

Ship ambient. In extreme hot weather, ship with a cool pack.

Causes for Rejection

Inadequate fixation; Improper labeling

Reference Range

Marker and tissue specific

Description

Results are reviewed by a board-certified pathologist to determine if tissues are positive or negative for the marker. These results may be used to assist in determining appropriate patient therapy or treatment. Immunohistochemistry combines the principles of histochemistry with the high degree of molecular specificity of the antibody-antigen reaction. The use of an enhanced-polymer detection system provides many benefits, including increased sensitivity, fewer procedural steps as compared to conventional techniques, and a reduction in non-specific background staining.
MPLN offers a range of markers by Immunohistochemistry including hematologic, tissue specific, infectious agents and proliferation antigens.

References
  1. Battifora et al. (1993). Appl Immunohistochem. 1:39-45.
  2. Perttschuk et al. (1996). Cancer. 77:2514-15.
  3. Press M et al. (2002). Steroids. 67:799-813.