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p16 by IHC

Test Code

I P16

Test Synonyms

Tumor suppressor gene, Cyclin-dependent kinase inhibitor 2A, CDKN2A, p16Ink4A

Associations

Head and Neck squamous cancer, myeloma, bladder cancer, cervical cancer. gastric cancer

Methodology

Immunohistochemistry

Turnaround Time

2 days

Specimen Requirements

Surgical samples received in 10% neutral buffered formalin
Formalin fixed paraffin embedded tissue
Previously prepared pathology materials (slides,smears, blocks or other samples)

Send reports, history and differential diagnosis

Specimen Stability
Indefinitely at room temperature
Storage & Handling

Ship ambient. In extreme hot weather, ship with a cool pack.

Causes for Rejection

Inadequate fixation; Improper labeling

Description

P16 plays an important role in regulating the cell cycle, and mutations in p16 increase the risk of developing a variety of cancers.

References
  1. Romagosa C et al.(2011.p16Ink4a overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors.Oncogene 30:2087-2097
  2. Kian Ang K et al. (2010).Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer. N Engl J Med 363:24-35.
  3. Lewis J,S et al. (2010). p16 Positive Oropharyngeal Squamous Cell Carcinoma: An Entity With a Favorable Prognosis Regardless of Tumor HPV Status. Am J Surg Pathol 34:1088–1096