Fluorescence in situ Hybridization (FISH)
*performed by affiliate laboratory
5.0 mL whole blood, sodium heparin
Protect from extreme temperature. Ship on Saturday for Monday delivery only if sample is Ship with cool pack (refrigerated). protected from extreme temperature.
Clotted specimen; Specimen exposed to extreme temperature; Anticoagulant toxic to cells; Insufficient number of cells
It is recommended that all FISH studies be done in conjunction with routine cytogenetic studies. If the FISH result is normal, a chromosome analysis allows identification of more complex abnormalities.
Some symptoms include neonatal hypotonia, absent/delayed speech, moderate/profound developmental delay as well as minor dysmorphic features, including dolicocephaly, periorbital fullness, long eyelashes, prominent/full brow, large fleshy hands, dysplastic toenail. Behavioral featues include decreased perception of pain, obsessive chewing or mouthing, autism or autistic-like affect.