M PML RARA*
PML RARA t(15;17) short form, PML RARA t(15;17) long form
Acute promyelocytic leukemia (APL), FAB M3;
Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) for PML/RARA t(15;17) long form and PML/RARA t(15;17) short form
*performed by affiliate laboratory
5 mL (Min.1 mL) whole blood; 3 mL (Min.1 mL) bone marrow; EDTA only
Specimens must be received within 48 hours of collection due to lability of RNA.
Ship peripheral blood and bone marrow with cool/refrigerated pack (Do not allow
cool/refrigerated pack to directly contact sample)
Please call before shipping on Friday for weekend delivery.
Specimen >48 hours old; Frozen Specimen; Specimen clotted; Stored or shipped at incorrect temperature; Incorrect anticoagulant; Insufficient specimen volume; Severely hemolyzed specimen
Positive: PML/RARA short or long fusion detected and quantified
Negative: PML/RARA short or long fusion not detected (0.002% PML/RARA)
Utilized for the determination of baseline PML/RARA fusion gene transcript levels and monitoring of same for molecular evidence of minimal residual disease (MRD) or molecular remission in patients with AML-M3 (APL) after induction and consolidation therapy.