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T-cell / NK-cell Lymphoma Markers by Immunohistochemistry (IHC)

Test Code

See associations below

Test Synonyms

Hematopoetic Markers

Associations
Test Code Description
I CD1a CD1a cortical thymocytes, Langerhans cells
I CD2 CD2 thymic, T-cells, NK cells
I CD3 CD3 pan T-cell antigen
I CD4 CD4 helper T-cells
I CD5 CD5 pan T-cell, B-cell subset, thymic carcinoma
I CD7 pan T-cells, NK cells and thymocytes
I CD8 CD8 suppressor T-cell
I CD43 CD43 T-cell, myeloid, B-cell subset, histiocytes
I CD56 CD56 NK cells
I CD57 CD57 neural, neuroendocrine, NK cells
I GRANB Granzyme B, cytotoxic T-cell subset, NK cell
Methodology

Immunohistochemistry
Technical component (TC) available for all markers.

Turnaround Time

2 days

Specimen Requirements

Formalin fixed tissue
Formalin fixed paraffin embedded tissue (preferred)

Specimen Stability
Indefinitely at room temperature
Storage & Handling

Ship ambient.
In extreme hot weather, ship with a cool pack.

Causes for Rejection

Inadequate fixation; Improper labeling

Reference Range

Marker and tissue specific

Description

Results are reviewed by a board-certified pathologist to determine if tissues are positive or negative for the marker. These results may be used to assist in determining appropriate patient therapy or treatment.
Immunohistochemistry combines the principles of histochemistry with the high degree of molecular specificity of the antibody-antigen reaction. The use of an enhanced-polymer detection system provides many benefits including increased sensitivity, fewer procedural steps as compared to conventional techniques, and a reduction in non-specific background staining. 

MPLN offers a range of markers by Immunohistochemistry including hematologic, tissue specific, infectious agents and proliferation antigens.

References
  1. Press M et al. (2002). Steroids. 67:799-813.
  2. Perttschuk et al. (1996). Cancer. 77:2514-15.
  3. Battifora et al. (1993). Appl Immunohistochem. 1:39-45.