h/o lung CA s/p taxotere/carboplatin in 2012-13
WBC 2900, HGB 10.1 g/dL, hct 30.6 %, MCV 97.0 fL; plt 56 k; absolute neutrophils 1340, absolute lymphocytes 1200, absolute monocytes 300
Bone marrow submitted
Atypical Megakaryocyte - small and hypolobated
Minor blast gate identified on left, hemodilution effect shown on right
Atypical Megakaryocytes - small and hypolobated
Less than 5% blasts on CD34 staining
Occasional ringed sideroblasts identified
- flow cytometry reveals 2.1% atypical myeloblasts (atypical dim partial CD7 and CD4 expression)
- increased storage iron present with occasional ringed sideroblasts identified
—-Await final SUMMARY report integrating pending FISH / cytogenetic testing
Loss of 5q, 7q, and 20q by FISH
Complex karyotype including 5q deletion, 7q deletion and monosomy 20, 21, 16, and 18
- flow cytometry reveals 2.1% atypical myeloblasts (atypical dim partial CD7 and CD4 expression)
- ABNORMAL FEMALE KARYOTYPE: 43,XX,del(5)(q15q33),del(7)(q22q34),add(15) (p10),-16,-18,-20,-21,+mar[6]/46,XX[14]
- FISH POSITIVE for loss of 5q in 30%, loss of 7q in 22%, and loss of 20q in 29% of cells
- increased storage iron present with occasional ringed sideroblasts identified (<15% of erythroid elements)