Beta 2 integrins
Type I and II leukocyte adhesion deficiency. Panel measures CD11b, CD15, and CD18 on neutrophils.
Semi-Quantitative Flow Cytometry
* Performed by affiliate laboratory
5 mL (min. 1 mL) sodium heparin or lithium heparin whole blood
Ship refrigerated. Protect from extreme temperature. Separate ice pack from specimen.
Clotted specimens. Frozen or room temperature specimens. Specimens greater than 48 hours.
The Leukocyte Adhesion Deficiency Panel measures the receptors CD11b, CD15, and CD18 on neutrophils. The percentage of patient neutrophils bearing these receptors is reported. Although these receptors are normally found on neutrophils; values outside of the reference interval may correlate with abnormal neutrophil function. For example, CD18 is decreased or absent in Leukocyte Adhesion Deficiency (LAD) type I and CD15 is decreased or absent in LAD type II.