deletion 6q23, del(6)(q23)
Chronic lymphocytic leukemia (CLL), Childhood acute lymphoblastic leukemia (ALL), B-cell small lymphocytic lymphoma (SLL), Plasma cell myeloma
Fluorescence in situ Hybridization (FISH)
5mL peripheral blood in sodium heparin
3mL bone marrow in sodium heparin
Fixed cytogenetically prepared cells in sterile centrifuge tube with pellet visible in 3:1, Methanol:Acetic Acid
4°C to 25°C during transit, but specimens may be transported on refrigerated gel packs. Do not allow the gel pack to come in contact with the specimen. Do not freeze. Extreme temperatures should be avoided.
Clotted specimen; Specimen exposed to extreme temperature; Anticoagulant toxic to cells; Insufficient number of cells
A normal cell will contain a two aqua signal pattern. In individuals with a deletion of the 6q23, there is a single aqua signal.
This abnormality has been associated with childhood acute lymphoblastic leukemia (ALL), adult ALL, B-cell small lymphocytic lymphoma, atypical chronic lymphocytic leukemia and plasma cell myeloma. FISH can detect this rearrangement in either interphase or metaphase cells.