Tumor suppressor gene, Cyclin-dependent kinase inhibitor 2A, CDKN2A, p16Ink4A
Head and Neck squamous cancer, myeloma, bladder cancer, cervical cancer. gastric cancer
Paraffin embedded tissue block
3 slides (3-5 uM) per marker on adhesion glass
Indefinitely at room temperature
Storage & Handling
Ship ambient. Protect from extreme temperature with an ice pack. Separate ice pack from specimen.
Causes for Rejection
Inadequate fixation; Improper labeling
P16 plays an important role in regulating the cell cycle, and mutations in p16 increase the risk of developing a variety of cancers.
- Romagosa C et al.(2011.p16Ink4a overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors.Oncogene 30:2087-2097
- Kian Ang K et al. (2010).Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer. N Engl J Med 363:24-35.
- Lewis J,S et al. (2010). p16 Positive Oropharyngeal Squamous Cell Carcinoma: An Entity With a Favorable Prognosis Regardless of Tumor HPV Status. Am J Surg Pathol 34:1088–1096