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Revolutionizing Clinical Trials: The Power of Digital Pathology

Revolutionizing Clinical Trials: The Power of Digital Pathology

Digital Pathology

The realm of clinical trials is continuously evolving, with digital pathology emerging as a transformative force. By shifting from traditional glass slides to digital counterparts, clinical trials are witnessing unprecedented efficiency, cost savings, and enhanced data management. Here’s a deep dive into the myriad benefits that digital pathology brings to the table.

The Value of Digital Pathology in Clinical Trials

1. Seamless Access to Digital Slides

Digital pathology eliminates the physical limitations associated with glass slides. Researchers can access digital slides from anywhere in the world, facilitating collaborative efforts and second opinions without the need for physical transportation. This is particularly valuable in clinical trials, where timely access to data can significantly impact study outcomes.

2. Enhanced Cost-Effectiveness

Switching to digital pathology is not just about convenience; it’s also about cost savings. A case in point is a previous client who saved over $1 million in a single study by transitioning to digital slides. These savings stem from reduced logistics, easier access to slides, and decreased need for physical storage space.

3. Simplified Retrieval and Compliance

Digital slides are easily retrievable compared to their glass counterparts. This ease of access is crucial, especially when slides need to be reviewed for FDA submissions or regulatory audits. Digital storage also ensures that source data originating from physical slides are preserved in pristine condition, free from the risks of breakage or degradation over time.

Our Comprehensive Digital Pathology Solution

At Molecular Pathology Laboratory Network (MPLN), we offer end-to-end digital pathology services, ensuring a seamless experience from imaging to storage. Our integrated approach means there are no third-party handovers, which could compromise data integrity or security. Here’s what we offer:

  • Digital Imaging: High-quality imaging of pathology slides using state-of-the-art equipment.
  • Data Transfer: Secure and efficient transfer of open-source digital image files to cloud storage.
  • Storage Setup: Reliable and scalable digital storage solutions, ensuring easy access and compliance with regulatory standards.

Supporting Decentralized Trials

One of digital pathology’s most significant advantages is its role in decentralized clinical trials. By enabling remote access to slides and data, digital pathology facilitates a decentralized model, allowing for broader and more globalized patient recruitment and participation. This is especially important for rare diseases or conditions where patient populations are dispersed.

Improving Patient Recruitment

Digital pathology can also play a pivotal role in improving patient recruitment. With digital slides, pathology results can be quickly shared with investigators and recruitment teams, speeding up identifying and onboarding eligible patients. This rapid turnaround is crucial in maintaining the momentum of clinical trials.

Ensuring Standardization

Standardization is key in clinical trials to ensure consistent and reproducible results. Digital pathology provides a platform for standardizing imaging and centralized review. This uniformity reduces variability and enhances the reliability of trial outcomes.

HALO AI: A Case Study in Opportunity

MPLN is currently working with a client to utilize advanced digital pathology software HALO AI for its robust analysis capabilities. For instance, in studies involving PD-L1 (Programmed Death-Ligand 1), HALO AI can perform precise quantification and analysis, aiding in the identification of biomarkers and assessment of therapeutic efficacy. This level of detail and accuracy is instrumental in driving successful trial outcomes.

Find Out More…

Digital pathology is revolutionizing clinical trials by offering unparalleled benefits in accessibility, cost-effectiveness, compliance, and data management. MPLN’s comprehensive digital pathology services ensure that you can focus on what matters most – advancing clinical research and improving patient outcomes. By embracing digital pathology, clinical trials can achieve new heights of efficiency and success.

Feel free to reach out to learn more about how MPLN can support your clinical trial needs with our cutting-edge digital pathology solutions. Together, let’s transform the future of clinical trials. 

    Project Management

    Our project managers have strong scientific backgrounds and extensive experience in complex research-based clinical trials. They collaborate with our scientific operations, client services, and commercial operations teams to deliver high-quality, regulatory-compliant testing results on time at every project step.

    Key Features

    • Studies are typically set up within 8 to 12 weeks of contract signature

    Benefits

    • Responsive communication with the scientific and operational teams

    Data Management

    The key to a successful clinical trial is accurate, clean, quality data. Our team of data managers provides you with data in customized formats exported to your data management teams from our in-house laboratory information system (LIS).

    Key Features

    • Access to dedicated and experienced data specialists upon contract award
    • Customized reports are agreed upon in study-specific data transfer agreement
    • Flexible data exports and data transfers

    Benefits

    • Real-time reports for your data and project teams to aid in patient management
    • Guaranteed data integrity and quality
    • Improved decision-making and enhanced patient safety
    • Timely access to accurate, clean data for intermediate or final database lock
    Genomic Solutions

    Genomic Solutions

    Genomic testing delivers powerful, patient-specific insights that guide precision oncology and inform the next generation of targeted therapies.

    Our genomic testing options uncover critical genetic markers that drive disease progression and influence individual treatment responses. This empowers healthcare professionals to create more precise, tailored treatment plans, optimizing medical management based on each patient’s genetic profile[click here to view testing options].

    DNA Solutions – WGS*, WGMS*, WES*, TSO Comp, Pillar OncoRevealSolid Tumor, Pillar Myeloid
    RNA Solutions – Total RNA-Seq*, RNA exome*, mRNA*
    Liquid Biopsy Solutions – PGDx elio™ plasma complete*

    Key Features

    • Targeted NGS panels, including FDA-approved assays with companion diagnostic designations.
    • Customized bioinformatics and reporting solutions.
    • Robust assay   to accommodate low-yielding biopsy material
    • Streamlined wet lab processes to meet screening window timelines

    Benefits

    • Identify variants along with key biomarker signatures
    • Save time and money by assessing multiple biomarkers in a single test
    • Enable targeted therapies with actionable, easy-to-interpret results
    • Assists in targeted patient stratification and recruitment
    • Accelerates the development of personalized medicine

    *Offered through fully accredited partner laboratories.

    Digital Pathology

    Digital Pathology

    Digital pathology revolutionizes clinical trials by enhancing accessibility, cost-efficiency, compliance, and data management. MPLN’s comprehensive digital pathology services streamline clinical research, allowing for improved patient outcomes and operational efficiency.

    Key Features

    • Cloud-based image managementplatform allows seamless access to digital images from anywhere around the globe.
    • Validated diagnostic workflows for primary diagnosis.
    • Digital imageworkflowsthat streamlinelogistics and reduce the need for physical slide storage and transportation.
    • Digital image transfer services and long-term secure image storage options are available.

    Benefits

    • Allows key opinion leaders (KOL) and remote client pathologists to be utilized in clinical trial workflows.
    • Enables efficient centralized review with simultaneous pathologist viewing.
    • Reduces the costs associated with physical slidetransport and storage
    • Simplifies regulatory processes, ensuring fasterand more accurate FDA submissions and audit readiness.
    • Prevents slide degradation or breakage, maintaining the quality of research datalong-term.
    • Enables broader patient recruitment by facilitating decentralized clinical trials for wider geographic participation, increasing patient recruitment and diversity.
    Global Logistics

    Global Logistics

    Effective global logistics are the cornerstone of effective specialty laboratory testing supporting global clinical trials. With precious patient samples such as biopsy and bone marrow aspirates, ensuring samples reach the lab on time and within stability is paramount.

    Key Features

    • Partnerships with global specialist couriers and large integrators to support global studies and specialty shipping requirements
    • Ambient, refrigerated, frozen, and liquid nitrogen storage and shipment services available
    • Real-time or batched shipments based on your clinical trial’s individual needs
    • Secure, high-volume, redundant data storage solutions for digital pathology images
    • Expert advice for effective sample collection, handling, and transport
    • Accurate tracking and inventory for all clinical trial specimens

    Benefits

    • Safe and effective transport of specimens worldwide
    • Standardized procedures to reduce pre-analytical variability and ensure valid results
    • Centralized and harmonized specialty pathology testing supported
    • Reduced costs and maximized budgets with fully managed logistics from one trusted source
    • Readily available inventories, manifests, and shipments for timely study closeouts
    Multiplex IHC clinical trial services

    IHC & Multiplex IHC

    Our advanced technology enables simultaneous visualization of single or multiple biomarkers within the same tissue section, delivering comprehensive insights and precise diagnostics. With unmatched expertise and cutting-edge technology, our team supports you in understanding complex tissue microenvironments, aiding patient stratification and treatment response prediction.

    Key Features

    • Over 200 IHC antibodies validated and ready for use in clinical trials [click here to view our IHC test menu].
    • Custom assay validation and flexible testing to meet unique research or clinical trial needs.
    • Simultaneous visualization ofmultiple biomarkers within the same tissue section.
    • Board-certified pathologists provide detailed data analysis and interpretation to ensure accurate results.

    Benefits

    • Gain comprehensive insights that lead to more precise diagnostics and better patient outcomes.
    • Enhanced ability to identify patient subgroups and better predict treatment responses.
    • Maximize information from small biopsy samples. (i.e.,NSCLC)
    • Whether in biomarker discovery or clinical trials, our advanced technology supports a range of applications, helping you unlock the full potential of your tissue samples.
    Cytogenetics FISH - clinical trial services

    Cytogenetics & FISH

    We offer a comprehensive range of chromosome analysis and fluorescent in situ hybridization (FISH) testing with industry-leading turnaround times and global coverage. Our board-certified lab directors and experienced cytogenetic technologists ensure accurate, efficient, and competitively priced testing with the highest quality of service.

    Key Features

    • Extensive FISH menu of over 40 loci and disease-specific panels detecting gene amplifications, deletions, translocations, and inversions [click here to view testing menu].
    • Testing is available on bone marrow, blood, and FFPE tissue samples.
    • Comprehensive chromosome analysis testing for oncology, infertility, recurrent pregnancy loss, and congenital disorders.
    • Fully harmonized services at accredited partner labs to support global clinical trials.

    Specialized Offerings:

    • Plasma cell enrichment for plasma disorders
    • Stat turnaround for PML::RARA and acute myeloid leukemia
    • Bladder cancer urine analysis
    • Custom FISH assay validation services

    Benefits:

    • Rapid, precise results that are critical for diagnosis and treatment.
    • Achieve comprehensive coverage for key genes indicated in the diagnosis and prognosis of hematological malignancies per the current WHO, NCCN, and ELN guidelines.
    • Expert-driven testing with board-certified experts ensures the highest accuracy.
    • Tailored assays and solutions to meet unique clinical trial needs.
    • Faster diagnostics to support timely treatment decisions.