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Carcinoma / Mesothelial Markers by Immunohostochemistry (IHC)

Test Code

See associations below

Associations
Test Code Description
I CALRT Calretinin; Calcium binding protein
I ERA Epithelial related antigen, MOC-31
I BEREP4 Epithelial antigen, BER-EP4
I TAG72 TAG 72, adenocarcinoma; HMW glycoprotein
I WT1 Wilms tumor
Methodology

Immunohistochemistry
Technical component (TC) available for all markers

Turnaround Time

2 days

Specimen Requirements

Formalin fixed tissue
Formalin fixed paraffin embedded tissue (preferred)
3 slides (3-5 uM) per marker on adhesion glass

Specimen Stability
Indefinitely at room temperature.
Storage & Handling

Ship ambient. Protect from extreme temperature with an ice pack. Separate ice pack from specimen.

Causes for Rejection

Inadequate fixation; Improper labeling

Reference Range

Marker and tissue specific

Description

Results are reviewed by a board-certified pathologist to determine if tissues are positive or negative for the marker. These results may be used to assist in determining appropriate patient therapy or treatment.
Immunohistochemistry combines the principles of histochemistry with the high degree of molecular specificity of the antibody-antigen reaction. The use of an enhanced-polymer detection system provides many benefits including increased sensitivity, fewer procedural steps as compared to conventional techniques, and a reduction in non-specific background staining. 


MPLN offers a range of markers by Immunohistochemistry including hematologic, tissue specific, infectious agents and proliferation antigens.

References
  1. Perttschuk et al. (1996). Cancer. 77:2514-15.
  2. Press M et al. (2002). Steroids. 67:799-813.
  3. Battifora et al. (1993). Appl Immunohistochem. 1:39-45.