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HER2 by IHC

Test Code

I HER2

Test Synonyms

PATHWAY (4B5), Immuno, Immunohistochemistry, Immunoperoxidase

Associations
Breast cancer; Herceptin
Methodology

Immunohistochemistry
Technical component (TC) available

Turnaround Time

2 days

Specimen Requirements

Formalin fixed paraffin embedded tissue block

Specimen Stability
Indefinitely
Storage & Handling

Ship blocks at ambient temperature.

Causes for Rejection

Improper specimen labeling; Insufficient sample; Inadequate fixation and/or processing

Reference Range

Normal breast tissues may produce positive reactivity scoring 1+ intensity, as will kidney, uterus and epithelium of the colon, stomach and small intestine. Normal tissues producing 2+ to 3+ staining intensity include esophageal epithelia, Langerhans cells, pituitary endocrine cells, prostate and squamous epithelia of tonsil.

Description

In a fraction of patients with breast cancer, the HER2 protein is over expressed as part of the process of malignant transformation and tumor progression.  Over expression of the HER2 protein on the surface of breast cancer cells suggest that it could be a target for antibody therapy, Herceptin (Trastuzumab).

References
  1. Coussens L et al. (1985). Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. Science. 230:1132-9.
  2. King CR, Kraus MH, Aaronson SA. (1985). Amplification of a novel v-erbB-related gene in a human mammary carcinoma. Science. 229:974-6.

 

Trademarks

HercepTest is a registered trademark of Genentech, Inc.