PATHWAY (4B5), Immuno, Immunohistochemistry, Immunoperoxidase
Technical component (TC) available
Formalin fixed paraffin embedded tissue block
Ship blocks at ambient temperature.
Improper specimen labeling; Insufficient sample; Inadequate fixation and/or processing
Normal breast tissues may produce positive reactivity scoring 1+ intensity, as will kidney, uterus and epithelium of the colon, stomach and small intestine. Normal tissues producing 2+ to 3+ staining intensity include esophageal epithelia, Langerhans cells, pituitary endocrine cells, prostate and squamous epithelia of tonsil.
In a fraction of patients with breast cancer, the HER2 protein is over expressed as part of the process of malignant transformation and tumor progression. Over expression of the HER2 protein on the surface of breast cancer cells suggest that it could be a target for antibody therapy, Herceptin (Trastuzumab).
HercepTest is a registered trademark of Genentech, Inc.