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Sarcoma, Tissue Markers by Immunohistochemistry (IHC)

Test Code

See associations below

Test Synonyms

Sarcoma, Vascular, Neural, Fibrohistiocytic, Muscle, GIST, Stromal Markers

Associations
Test Code Description
I ALK Anaplastic lymphoma kinase - 1
I CD10 Common ALL antigen
I CD31 CD31 endothelial cells
I CD34 CD34 endothelial, stem cells, stromal cells
I CD56 NK cell
I CD99 Ewings sarcoma, PNET
I CD117 CD117 C-kit, myeloid and mast cell
I D2 40 D2-40, Podoplanin
I DESMIN Desmin filament protein
I DOG1 DOG1, derived from GIST 1
I EMA Epithelial membrane antigen
I FXIIIA Factor XIIIa fibrohistiocytic, dendritic cells
I MSA Muscle Specific Actin
I MYOGEN Myogenin muscle marker
I MYOGLB Myoglobin cardiac, skeletal
I PDGFR Platelet derived growth factor receptor alpha
I S100 S100 protein
I SMA Smooth muscle actin
I SMM Smooth muscle myosin
I VIM Vimentin
I WT1 Wilms tumor

 

Methodology

Immunohistochemistry
Technical component (TC) available for all markers.

Turnaround Time

2 days

Specimen Requirements

Formalin fixed tissue
Formalin fixed paraffin embedded tissue (preferred)

Specimen Stability
Indefinitely at room temperature
Storage & Handling

Ship ambient.
In extreme hot weather ship with a cool pack.

Causes for Rejection

Inadequate fixation; Improper labeling

Reference Range

Marker and tissue specific

Description

Results are reviewed by a board-certified pathologist to determine if tissues are positive or negative for the marker. These results may be used to assist in determining appropriate patient therapy or treatment.
Immunohistochemistry combines the principles of histochemistry with the high degree of molecular specificity of the antibody-antigen reaction. The use of an enhanced-polymer detection system provides many benefits including increased sensitivity, fewer procedural steps as compared to conventional techniques, and a reduction in non-specific background staining.

MPLN offers a range of markers by Immunohistochemistry including hematologic, tissue specific, infectious agents and proliferation antigens

References
  1. Press M et al. (2002). Steroids. 67:799-813.
  2. Perttschuk et al. (1996). Cancer. 77:2514-15.
  3. Battifora et al. (1993). Appl Immunohistochem. 1:39-45.